Change the destination of Mac screenshots

1. Create a directory

e.g. Create Screenshots directory on Desktop

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cd ~/Desktop
mkdir Screenshots

2. Set the directory as the destination

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defaults write com.apple.screencapture location ~/Desktop/Screenshots/;killall SystemUIServer

Tips

Action Command
Entire screen [command]+[shift]+[3]
Selected range [command]+[shift]+[4]
Only selected window [command]+[shift]+[space]+[4]
Display control [command]+[shift]+[5]
Copy to clipboard [command]+[shift]+[control]+[3/4]